BMS-986449
编号: 25119
Cas号:
纯度: 98% Min.
BMS-986449 is a CELMoD molecular glue that redirects the E3 ubiquitin ligase Cereblon to interact with and induce the degradation of Helios and Eos. It was optimized to induce rapid and deep degradation of Helios and Eos in primary Treg cells with selectivity over other CELMoD neosubstrates, as assessed by global proteomic analysis of primary T cells.
仅供研究使用。 我们不向患者出售。
化学信息
| 名称 | BMS-986449 |
|---|---|
| Iupac 化学名称 | (S)-3-((R)-5-(6-amino-4,5-dimethylpyridin-2-yl)-4-fluoro-3-methyl-1-oxoisoindolin-2-yl)piperidine-2,6-dione |
| 同义词 | BMS-986449; BMS986449; BMS 986449 |
| 英文同义词 | BMS-986449; BMS986449; BMS 986449 |
| 分子式 | C21H21FN4O3 |
| 分子量 | 396.41 |
| Smile | O=C1NC([C@@H](N2[C@H](C)C3=C(F)C(C4=CC(C)=C(C)C(N)=N4)=CC=C3C2=O)CC1)=O |
| InChiKey | CNRNDVOTRSDMEF-ABAIWWIYSA-N |
| InChi | InChI=1S/C21H21FN4O3/c1-9-8-14(24-19(23)10(9)2)12-4-5-13-17(18(12)22)11(3)26(21(13)29)15-6-7-16(27)25-20(15)28/h4-5,8,11,15H,6-7H2,1-3H3,(H2,23,24)(H,25,27,28)/t11-,15+/m1/s1 |
| Cas号 | |
| 相关CAS号 |
订购信息
| 包装 | 价格 | 库存 | 纯度 | 备货期 |
|---|---|---|---|---|
| 大货 | 询价 | 询价 | 询价 |
| 外观性状 | 类白色固体 |
|---|---|
| 纯度 | 98% Min. |
| 存储 | 0-4℃，可保存几天到几周；-20℃，可保存 几个月。 |
| 可溶性 | 溶于DMSO等有机溶剂 |
| 处理方式 | |
| 运输条件 | 可以在室温下进行运输。 |
| 海关编码 |
Coming soon.
| Targets | |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
[1]. Barnes M J. Selective degradation of Helios induces Treg cell reprogramming and enhanced antitumor immunity[J]. Cancer Research, 2025, 85(8_Supplement_1): 2249-2249.
